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Total Syntheses of Cytotoxic, Naturally Occurring Kalasinamide, Geovanine, and Marcanine A
Author(s) -
Lang Steffen,
Groth Ulrich
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804388
Subject(s) - computer science , chemistry , information retrieval , combinatorial chemistry
Two novel synthetic strategies were developed for the natural products geovanine, marcanine A, and kalasinamide. The nine‐step synthesis of geovanine marks its first total synthesis. The three compounds are known for their antimalarial and antitumor activity, and tests confirmed the high cytotoxity of marcanine A.