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Copper–Nitrene Complexes in Catalytic CH Amination
Author(s) -
Badiei Yosra M.,
Dinescu Adriana,
Dai Xuliang,
Palomino Robert M.,
Heinemann Frank W.,
Cundari Thomas R.,
Warren Timothy H.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804304
Subject(s) - nitrene , amination , catalysis , chemistry , benzene , stoichiometry , intermolecular force , medicinal chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , molecule
Hydrocarbons activate! Isolable β‐diketiminato dicopper–nitrene complexes such as 1 derived from the reaction of [{(Cl 2 NN)Cu} 2 (μ‐benzene)] and 1‐adamantylazide are potent towards nitrene insertion into unactivated sp 3 ‐hybridized CH bonds. 1 allows stoichiometric and catalytic intermolecular CH amination of hydrocarbons to give secondary amines (see scheme). Catalyst loadings as low as 0.05 mol % may be used.