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Radical Allylation with α‐Branched Allyl Sulfones
Author(s) -
Charrier Nicolas,
Zard Samir Z.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804298
Subject(s) - isomerization , chemistry , trimethylsilyl , reagent , isopropyl , branching (polymer chemistry) , sulfone , organic chemistry , catalysis
Branching out with sulfones : The use of allyl isopropyl sulfones solves the problem of premature isomerization and allows the radical addition of xanthates to α‐branched allyl sulfones (see scheme; DCE=1,2‐dichloroethane, TMS=trimethylsilyl). Highly functionalized structures can thus be rapidly assembled under mild reaction conditions by using cheap and readily available substrates and reagents.