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Crystal Structure and Mechanism of a DNA (6‐4) Photolyase
Author(s) -
Maul Melanie J.,
Barends Thomas R. M.,
Glas Andreas F.,
Cryle Max J.,
Domratcheva Tatiana,
Schneider Sabine,
Schlichting Ilme,
Carell Thomas
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804268
Subject(s) - photolyase , lesion , dna , dna repair , mechanism (biology) , oxetane , computer science , computational biology , information retrieval , biology , chemistry , physics , genetics , medicine , surgery , quantum mechanics , polymer chemistry
Before and after : Crystal structures of the DNA (6‐4) photolyase from D. melanogaster —one structure in complex with DNA containing a (6‐4) lesion (see picture) and one in which the lesion has been repaired—provide new insight into lesion recognition and repair. The proposed mechanism for light‐induced, electron‐transfer‐based repair of the (6‐4) lesion does not proceed via an oxetane intermediate.