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A DNA Nanostructure for the Functional Assembly of Chemical Groups with Tunable Stoichiometry and Defined Nanoscale Geometry
Author(s) -
Mitchell Nick,
Schlapak Robert,
Kastner Markus,
Armitage David,
Chrzanowski Wojciech,
Riener Johannes,
Hinterdorfer Peter,
Ebner Andreas,
Howorka Stefan
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804264
Subject(s) - nanostructure , nanoscopic scale , stoichiometry , supramolecular chemistry , streptavidin , dna origami , disulfide bond , tetrahedron , nanotechnology , crystallography , dna , chemistry , materials science , biotin , information retrieval , computer science , crystal structure , biochemistry , organic chemistry
Many legs make light work : Tetrahedra are constructed with edges of double‐stranded DNA and vertices tagged with biotin or disulfide units (see picture). They can act as supramolecular scaffolds to combine different chemical groups at defined nanoscale distances and with tunable stoichiometries. The disulfide groups bind to gold surfaces with high affinity, which leaves the biotin unit poised to capture streptavidin.