Asymmetric Synthesis of 5‐(1‐Hydroxyalkyl)tetrazoles by Catalytic Enantioselective Passerini‐Type Reactions | Zendy

Yue Tao | Zendy; Wang MeiXiang | Zendy; Wang DeXian | Zendy; Zhu Jieping | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Asymmetric Synthesis of 5‐(1‐Hydroxyalkyl)tetrazoles by Catalytic Enantioselective Passerini‐Type Reactions

Author(s) -

Yue Tao,

Wang MeiXiang,

Wang DeXian,

Zhu Jieping

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200804213

Subject(s) - enantioselective synthesis , catalysis , acrolein , chemistry , hydrazoic acid , enantiomeric excess , toluene , substrate (aquarium) , enantiomer , organic chemistry , combinatorial chemistry , oceanography , geology

Three‐part harmony : Three‐component Passerini reactions (P‐3CR, see Scheme) of a wide range of aldehydes 2 and isocyanides 3 , with hydrazoic acid 4 in toluene, in the presence of a [(salen)AlMe]‐complex catalyst afford 5‐(1‐hydroxyalkyl)tetrazoles 1 in good‐to‐excellent yields and enantiomeric excess. A tandem Michael addition/enantioselective P‐3CR, using an acrolein substrate, affords highly functionalized tetrazoles.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research