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Effective Binding and Sensing of Lipopolysaccharide: Combining Complementary Pattern Recognition Receptors
Author(s) -
Ganesh V.,
Bodewits Karin,
Bartholdson S. Josefin,
Natale Daniela,
Campopiano Dominic J.,
MarequeRivas Juan C.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804168
Subject(s) - receptor , zinc finger , hydrogen bond , lipopolysaccharide , zinc , chemistry , computational biology , biochemistry , combinatorial chemistry , biology , molecule , gene , organic chemistry , immunology , transcription factor
Nature inspired : A synthetic receptor (see picture) that exploits two zinc(II) ions and four convergent amino hydrogen bonding groups binds lipopolysaccharides (LPSs) almost as strongly as the LPS binding protein. This feature is exploited to electrochemically distinguish LPS from other pathogens in water and in complex biological mixtures. Zn pink, N blue, P orange, O red.