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Shuttle‐Based Fluorogenic Silver‐Cluster Biolabels
Author(s) -
Yu Junhua,
Choi Sungmoon,
Dickson Robert M.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804137
Subject(s) - cluster (spacecraft) , cluster analysis , chemistry , combinatorial chemistry , fluorescence , computer science , computational biology , nanotechnology , materials science , physics , artificial intelligence , biology , programming language , quantum mechanics
Clustering together : A shuttle‐based fluorogenic cluster transfer, in which silver clusters (SCs) are directly transferred from a low‐molecular‐weight poly(acrylic acid) (PA) shuttle to a single‐stranded DNA (ssDNA) tag on the protein of interest (see picture), proceeds with excellent specificity. Upon transfer, the cluster fluorescence increases more than ten times, which provides bright, photostable labeling.