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Polymeric Core–Shell Assemblies Mediated by Host–Guest Interactions: Versatile Nanocarriers for Drug Delivery
Author(s) -
Zhang Jianxiang,
Ma Peter X.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804135
Subject(s) - nanocarriers , micelle , copolymer , drug delivery , nanotechnology , polymer , host (biology) , block (permutation group theory) , chemistry , core (optical fiber) , computer science , combinatorial chemistry , materials science , organic chemistry , aqueous solution , ecology , geometry , mathematics , biology , telecommunications
First class delivery : Core–shell structured nanoassemblies could be constructed from a hydrophilic–hydrophilic block copolymer with one block containing β‐cyclodextrin in the presence of hydrophobic guest compounds (see picture). The polymer can host various guest molecules, while the difference in sensitivity can be utilized to regulate release rate. By selecting appropriate guests, polyion complex (PIC) micelles could also be assembled.