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Transition‐Metal‐Catalyzed Propargylic Substitution
Author(s) -
Ljungdahl Natalie,
Kann Nina
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804114
Subject(s) - substitution (logic) , catalysis , allylic rearrangement , amination , transition metal , chemistry , substitution reaction , combinatorial chemistry , organic chemistry , computer science , programming language
Keen for a share in the glory : Until recently, the title reaction stood in the shadows, its famous sister, catalytic allylic substitution, in the limelight. Catalytic propargylic substitution has now emerged as an efficient transformation that can be catalyzed by a variety of transition metals (see picture). Among the recent developments are copper‐catalyzed asymmetric propargylic amination reactions. Nu = nucleophile