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A Synthetic Ion Channel Derived from a Metallogallarene Capsule That Functions in Phospholipid Bilayers
Author(s) -
Kulikov Oleg V.,
Li Ruiqiong,
Gokel George W.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804099
Subject(s) - capsule , tetramer , bilayer , chemistry , ion channel , phospholipid , lipid bilayer , ion transporter , membrane , biochemistry , biology , botany , receptor , enzyme
Changing the channel : Dodecanal and pyrogallol were condensed to give a tetramer, which was crystallized as the bilayer and the hexameric molecular capsule. A copper‐seamed metallogallarene capsule functioned as an ion transporter and showed selectivity for potassium over chloride ion transport in a phospholipid bilayer (see picture). The capsule also showed voltage‐dependent gating of its open–close behavior when examined in asolectin membranes.