A Synthetic Ion Channel Derived from a Metallogallarene Capsule That Functions in Phospholipid Bilayers | Zendy

Kulikov Oleg V. | Zendy; Li Ruiqiong | Zendy; Gokel George W. | Zendy

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A Synthetic Ion Channel Derived from a Metallogallarene Capsule That Functions in Phospholipid Bilayers

Author(s) -

Kulikov Oleg V.,

Li Ruiqiong,

Gokel George W.

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200804099

Subject(s) - capsule , tetramer , bilayer , chemistry , ion channel , phospholipid , lipid bilayer , ion transporter , membrane , biochemistry , biology , botany , receptor , enzyme

Changing the channel : Dodecanal and pyrogallol were condensed to give a tetramer, which was crystallized as the bilayer and the hexameric molecular capsule. A copper‐seamed metallogallarene capsule functioned as an ion transporter and showed selectivity for potassium over chloride ion transport in a phospholipid bilayer (see picture). The capsule also showed voltage‐dependent gating of its open–close behavior when examined in asolectin membranes.

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