Premium
Versatile Biocompatible Polymer Hydrogels: Scaffolds for Cell Growth
Author(s) -
Khan Ferdous,
Tare Rahul S.,
Oreffo Richard. O. C.,
Bradley Mark
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804096
Subject(s) - self healing hydrogels , biocompatible material , cationic polymerization , polymer , chitosan , polymer science , cell culture , nanotechnology , chemistry , materials science , polymer chemistry , biochemistry , biomedical engineering , biology , engineering , organic chemistry , genetics
Gelling together : A three‐dimensional, biocompatible hydrogel (see picture) was generated by combining two cationic polymers, chitosan and poly(ethylenimine). The hydrogels were stable under cell‐culture conditions and facilitated cell proliferation, yet prevented dedifferentiation of primary human skeletal cells into fibroblasts. A variety of materials such as DNA, proteins, and peptides can be stably incorporated into the gel network.