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Self‐Assembly of One‐ and Two‐Dimensional Hemoprotein Systems by Polymerization through Heme–Heme Pocket Interactions
Author(s) -
Kitagishi Hiroaki,
Kakikura Yasuaki,
Yamaguchi Hiroyasu,
Oohora Koji,
Harada Akira,
Hayashi Takashi
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804006
Subject(s) - heme , hemeprotein , moiety , supramolecular chemistry , chemistry , polymerization , polymer , non covalent interactions , molecule , crystallography , stereochemistry , biochemistry , organic chemistry , hydrogen bond , enzyme
Supramolecular protein polymers : When a heme moiety was introduced to the surface of an apo‐cytochrome b 562 (H63C) mutant, supramolecular polymers formed through noncovalent heme–heme pocket interactions. The incorporation of a heme triad as a pivot molecule in the protein polymer further led to a two‐dimensional protein network structure, which was visualized by tapping‐mode atomic force microscopy (see picture).