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Molecular Engineering of Photoremovable Protecting Groups for Two‐Photon Uncaging
Author(s) -
Gug Sylvestre,
Bolze Frédéric,
Specht Alexandre,
Bourgogne Cyril,
Goeldner Maurice,
Nicoud JeanFrançois
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803964
Subject(s) - transparency (behavior) , combinatorial chemistry , fluorene , computer science , chemistry , window (computing) , nanotechnology , materials science , computer security , world wide web , organic chemistry , polymer
Open the cage : Symmetrical photoremovable bis‐glutamate cages have been designed, synthesized, and characterized that can release a neurotransmitter with unprecedented two‐photon efficiencies (see picture), up to 5 GM for BNSF–Glu (BNSF=2,7‐bis‐{4‐nitro‐8‐[3‐(2‐propyl)‐styryl]}‐9,9‐bis‐[1‐(3,6‐dioxaheptyl)]‐fluorene) at 800 nm, the optimal window both for tissue transparency and classically available laser sources.