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Lewis Acid Catalyst Free Electrophilic Alkylation of Silicon‐Capped π Donors in 1,1,1,3,3,3‐Hexafluoro‐2‐propanol
Author(s) -
Ratnikov Maxim O.,
Tumanov Vasily V.,
Smit William A.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803927
Subject(s) - electrophile , reagent , catalysis , lewis acids and bases , chemistry , solvent , alkylation , combinatorial chemistry , donation , organic chemistry , political science , law
A credit to donation : A diverse range of electrophilic addition reactions, conventionally carried out using Lewis acid catalysts, have been performed in electrophilic media without acidic reagents. 1,1,1,3,3,3‐Hexafluoro‐2‐propanol (HFIP) acts as an efficient hydrogen‐bond donor and highly polar solvent for a wide range of substrates in reactions with Si‐capped π donors.