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Synthesis of Cyclobutenes by Highly Selective Transition‐Metal‐Catalyzed Ring Expansion of Cyclopropanes
Author(s) -
Xu Huadong,
Zhang Wen,
Shu Dongxu,
Werness Jenny B.,
Tang Weiping
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803910
Subject(s) - carbene , regioselectivity , ring (chemistry) , stereospecificity , catalysis , cyclopropane , transition metal , chemistry , reactivity (psychology) , combinatorial chemistry , selectivity , metal , stereochemistry , medicinal chemistry , organic chemistry , medicine , alternative medicine , pathology
A highly chemoselective , regioselective, and stereospecific synthesis of polysubstituted cyclobutenes, by catalyst‐controlled ring expansion of cyclopropanes via metal carbene intermediates, is reported. Transition‐metal catalysts showed profound effects on the reactivity and selectivity of metal carbene intermediates in this ring‐expansion reaction.