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Structural Studies of Copper(I) Complexes of Amyloid‐β Peptide Fragments: Formation of Two‐Coordinate Bis(histidine) Complexes
Author(s) -
Himes Richard A.,
Park Ga Young,
Siluvai Gnana Sutha,
Blackburn Ninian J.,
Karlin Kenneth D.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803908
Subject(s) - library science , chemistry , polymer science , computer science
The beta bind : Copper(I) binds to amyloid β‐peptide fragments (see structure) as a stable bis(histidine), two‐coordinate, near‐linear complex, even in the presence of potential additional ligands. As has been proposed or assumed in other studies, the copper(I)–peptide complexes react with dioxygen to form the reactive oxygen species H 2 O 2 , without the need for a third histidine ligand to promote the chemistry.