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Fluorous Synthesis of 18 F Radiotracers with the [ 18 F]Fluoride Ion: Nucleophilic Fluorination as the Detagging Process
Author(s) -
Bejot Romain,
Fowler Thomas,
Carroll Laurence,
Boldon Sophie,
Moore Jane E.,
Declerck Jérôme,
Gouverneur Véronique
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803897
Subject(s) - fluoride , distillation , extraction (chemistry) , chemistry , ion , process (computing) , radiochemistry , combinatorial chemistry , computer science , chromatography , organic chemistry , inorganic chemistry , programming language
Tag team : The fluoro‐detagging of fluorous sulfonates by the [ 18 F]fluoride ion was found to be an advantageous strategy for the preparation of various 18 F‐labeled prosthetic groups and known radiotracers (see picture). Fluorous solid phase extraction (FSPE) was used to separate the excess fluorous precursor from the labeled material, which suggests that traditional purification protocols such as distillation or tedious separation can be avoided.