Mass Spectrometry Signal Amplification Method for Attomolar Detection of Antigens Using Small‐Molecule‐Tagged Gold Microparticles | Zendy

Lee Jung Rok | Zendy; Lee Juhee | Zendy; Kim Sang Kyung | Zendy; Kim Kwang Pyo | Zendy; Park Hyung Soon | Zendy; Yeo WoonSeok | Zendy

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Mass Spectrometry Signal Amplification Method for Attomolar Detection of Antigens Using Small‐Molecule‐Tagged Gold Microparticles

Author(s) -

Lee Jung Rok,

Lee Juhee,

Kim Sang Kyung,

Kim Kwang Pyo,

Park Hyung Soon,

Yeo WoonSeok

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200803893

Subject(s) - mass spectrometry , detection limit , chemistry , chromatography , matrix (chemical analysis) , analytical chemistry (journal) , nanotechnology , materials science

Small but more than enough : Proteins are detected in solution without additional amplification or labeling steps by using a small molecule as a reporter of the protein (see picture, Am‐tag=amplification tag). The combination of self‐assembled monolayers on gold with matrix‐free laser desorption/ionization time‐of‐flight mass spectrometry offers ultrahigh sensitivity with a detection limit of several attomoles.

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