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Iridium‐Catalyzed Highly Enantioselective Hydrogenation of the CC Bond of α, β‐Unsaturated Ketones
Author(s) -
Lu WeiJing,
Chen YunWei,
Hou XueLong
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803872
Subject(s) - iridium , enantioselective synthesis , catalysis , trifluoromethyl , ligand (biochemistry) , asymmetric hydrogenation , chemistry , organic chemistry , medicinal chemistry , combinatorial chemistry , biochemistry , alkyl , receptor
A fine selection : The installation of chiral centers at the α position of ketones is achieved with excellent enantioselectivity by means of iridium‐catalyzed asymmetric hydrogenation of α,β‐unsaturated ketones under mild conditions. The catalyst incorporates a phosphinooxazoline (PHOX)‐based ligand, which exhibits high levels of asymmetric induction (see scheme; BAr F − =tetrakis[3,5‐bis(trifluoromethyl)phenyl]borate; cod=cyclooctadiene).
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