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Cross‐Coupling of Aryl/Alkenyl Pivalates with Organozinc Reagents through Nickel‐Catalyzed CO Bond Activation under Mild Reaction Conditions
Author(s) -
Li BiJie,
Li YiZhou,
Lu XingYu,
Liu Jia,
Guan BingTao,
Shi ZhangJie
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803814
Subject(s) - aryl , nickel , reagent , catalysis , chemistry , coupling reaction , coupling (piping) , medicinal chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , materials science , metallurgy , alkyl
Finding the right partner : The catalyst system [NiCl 2 (PCy 3 ) 2 ] mediates the title transformation with high efficiency and allows aryl–aryl and vinyl–aryl coupling to proceed. The first example of catalytic cross‐coupling using the pivalates and organozinc reagents is described (see scheme; Cy=cyclohexyl, piv=pivalate).