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Controlling Curvature in a Family of Oligoamide α‐Helix Mimetics
Author(s) -
Saraogi Ishu,
Incarvito Christopher D.,
Hamilton Andrew D.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803778
Subject(s) - curvature , mimicry , helix (gastropod) , hydrogen bond , computer science , chemistry , crystallography , computational biology , biology , molecule , mathematics , geometry , ecology , organic chemistry , snail
Catching up with the curve! The natural curvature found in a majority of α helices has been mimicked in small synthetic oligoamide scaffolds. Differences in hydrogen‐bonding patterns in these scaffolds lead to mimetics with varying degrees of curvature in the backbone. This adds another parameter to the structural and functional mimicry of α helices.