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Biaryl Formation Involving Carbon‐Based Leaving Groups: Why Not?
Author(s) -
Bonesi Sergio M.,
Fagi Maurizio,
Albini Angelo
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803777
Subject(s) - nucleophile , electrophile , leaving group , chemistry , group (periodic table) , carbon fibers , combinatorial chemistry , substrate (aquarium) , unit (ring theory) , organic chemistry , catalysis , computer science , psychology , biology , algorithm , composite number , ecology , mathematics education
No loss, no gain : In the synthesis of biaryls either the electrophilic or nucleophilic partner can be replaced by a substrate with a carbon‐based leaving group (see scheme). Whereas replacing the electrophilic unit is not worthwhile, the use of nucleophiles with a C‐based leaving group has decisive advantages.