Biaryl Formation Involving Carbon‐Based Leaving Groups: Why Not? | Zendy

Bonesi Sergio M. | Zendy; Fagi Maurizio | Zendy; Albini Angelo | Zendy

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Biaryl Formation Involving Carbon‐Based Leaving Groups: Why Not?

Author(s) -

Bonesi Sergio M.,

Fagi Maurizio,

Albini Angelo

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200803777

Subject(s) - nucleophile , electrophile , leaving group , chemistry , group (periodic table) , carbon fibers , combinatorial chemistry , substrate (aquarium) , unit (ring theory) , organic chemistry , catalysis , computer science , psychology , biology , algorithm , composite number , ecology , mathematics education

No loss, no gain : In the synthesis of biaryls either the electrophilic or nucleophilic partner can be replaced by a substrate with a carbon‐based leaving group (see scheme). Whereas replacing the electrophilic unit is not worthwhile, the use of nucleophiles with a C‐based leaving group has decisive advantages.

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