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Radical Catalysis of Kumada Cross‐Coupling Reactions Using Functionalized Grignard Reagents
Author(s) -
Manolikakes Georg,
Knochel Paul
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803730
Subject(s) - aryl , reagent , palladium , chemistry , catalysis , iodide , alkyl , coupling reaction , combinatorial chemistry , organic chemistry
Palladium, radically different : A wide range of polyfunctional aryl‐ and heteroarylmagnesium reagents undergo fast Kumada cross‐couplings (see scheme) with functionalized aryl bromides in the presence of a palladium catalyst and an alkyl iodide as additive. These reactions proceed by a radical pathway.