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Highlights in Steroid Chemistry: Total Synthesis versus Semisynthesis
Author(s) -
Nising Carl F.,
Bräse Stefan
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803720
Subject(s) - semisynthesis , natural product , total synthesis , steroid , chemistry , biosynthesis , steroid biosynthesis , stereochemistry , combinatorial chemistry , biochemistry , gene , hormone
Many routes to the destination : Cortistatins are steroids of marine origin of which cortistatin A has the highest antiangiogenetic action. Several total syntheses of this natural product have recently been achieved, based on biosynthesis, biomimetic synthesis, semisynthesis, and de novo synthesis, which are compared in this Highlight.