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Highly Enantioselective Synthesis of Optically Active Ketones by Iridium‐Catalyzed Asymmetric Hydrogenation
Author(s) -
Lu ShengMei,
Bolm Carsten
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803709
Subject(s) - iridium , enantioselective synthesis , catalysis , optically active , asymmetric hydrogenation , combinatorial chemistry , chemistry , organic chemistry
Close to perfect enantioselectivity (up to 99 % ee , see scheme) is found for the formation of α‐substituted ketones by the asymmetric hydrogenation of enones with an iridium–phosphinooxazoline catalyst. In an operationally simple process, both linear and cyclic substrates react well and afford the desired products in high yields. A wide variety of substituents are tolerated, thus making the method synthetically appealing.