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Lewis Base Assisted Brønsted Base Catalysis: Bidentate Phosphine Oxides as Activators and Modulators of Brønsted Basic Lanthanum–Aryloxides
Author(s) -
Morimoto Hiroyuki,
Yoshino Tatsuhiko,
Yukawa Takafumi,
Lu Gang,
Matsunaga Shigeki,
Shibasaki Masakatsu
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803682
Subject(s) - lewis acids and bases , denticity , phosphine oxide , chemistry , phosphine , base (topology) , lanthanum , aryl , catalysis , brønsted–lowry acid–base theory , medicinal chemistry , combinatorial chemistry , organic chemistry , mathematics , crystal structure , mathematical analysis , alkyl
Dynamic Duo : A Lewis basic bidentate phosphine oxide was effective for activating and modulating the properties of Brønsted basic lanthanum aryl oxides. The Lewis base 1 /lanthanum aryl oxide system was suitable for anti ‐selective Mannich‐type reactions of trichloromethyl ketones (see scheme), affording unique building blocks for azetidine‐2‐carboxylic acids as well as β‐amino acids.