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Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell‐Wall Hydrolysis
Author(s) -
HernándezRocamora Víctor M.,
Maestro Beatriz,
de Waal Bas,
Morales María,
García Pedro,
Meijer E. W.,
Merkx Maarten,
Sanz Jesús M.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803664
Subject(s) - autolysis (biology) , dendrimer , choline , chemistry , biochemistry , cell wall , enzyme , streptococcus pneumoniae , cell , hydrolysis , bacterial cell structure , bacteria , microbiology and biotechnology , biology , genetics , antibiotics
Dendritic cell‐wall mimics: Choline‐binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline‐functionalized dendrimers are potent inhibitors of these essential enzymes, with a 10 3 –10 4 ‐fold higher affinity than free choline, resulting in inhibition of autolysis and cell separation in bacterial cultures at low micromolar concentrations (see picture).