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A High‐Yielding Biocatalytic Process for the Production of 2‐ O ‐(α‐ D ‐glucopyranosyl)‐ sn ‐glycerol, a Natural Osmolyte and Useful Moisturizing Ingredient
Author(s) -
Goedl Christiane,
Sawangwan Thornthan,
Mueller Mario,
Schwarz Alexandra,
Nidetzky Bernd
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803562
Subject(s) - glycerol , chemistry , sucrose , yield (engineering) , glycoside , ingredient , food science , organic chemistry , biochemistry , combinatorial chemistry , materials science , metallurgy
Fit for industry : Stereochemically pure 2‐ O ‐(α‐ D ‐glucopyranosyl)‐ sn ‐glycerol (αGG) was obtained in high yield from an efficient and selective biocatalytic process (see schematic outline). The sucrose phosphorylase catalyzed transfer of a glucosyl group from sucrose to glycerol unites the main advantages of transglycosidases, glycosyltransferases, and glycosynthases for glycoside synthesis and provides access to αGG as an industrial chemical.