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Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier
Author(s) -
Wang YingYing,
Lai Samuel K.,
Suk Jung Soo,
Pace Amanda,
Cone Richard,
Hanes Justin
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803526
Subject(s) - mucus , ethylene glycol , peg ratio , nanoparticle , penetration (warfare) , cervical mucus , adhesive , nanotechnology , chemistry , polymer science , materials science , biochemistry , biology , engineering , organic chemistry , operations research , ecology , finance , ovulation , layer (electronics) , hormone , economics
Outsmarting the barrier : Conventional poly(ethylene glycol) (PEG) coated particles (green with light purple border) are immobilized in human mucus networks by adhesive interactions (red) with the mucus mesh (black lines). A dense, low molecular weight PEG coating (blue) uniquely endows nanoparticles with a mucoinert surface that enables their rapid mucus penetration (trajectory indicated by grey line).