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Asymmetric Cross‐Coupling of Non‐Activated Secondary Alkyl Halides
Author(s) -
Glorius Frank
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803509
Subject(s) - negishi coupling , halide , alkyl , chemistry , coupling (piping) , nickel , catalysis , coupling reaction , organic chemistry , combinatorial chemistry , materials science , metallurgy
A new star is born : First reports on asymmetric cross‐coupling reactions of racemic activated and non‐activated secondary alkyl halides highlight the particular suitability of nickel catalysts for these reactions. Impressively high enantioselectivities were observed for Negishi, Hiyama, and Suzuki–Miyaura cross‐coupling reactions (see scheme). The results can be expected to change retrosynthetic thinking.