Premium
An Efficient Approach to Substituted 1,5,7,8,9‐Pentahydrocyclopenta[ h ]‐2‐Benzopyran‐3‐one Derivatives by a Palladium‐Catalyzed Tandem Reaction of 2,7‐Alkadiynylic Carbonates with 2,3‐Allenoic Acids
Author(s) -
Lian Xiongdong,
Ma Shengming
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803424
Subject(s) - regioselectivity , palladium , intramolecular force , catalysis , benzopyran , chemistry , substrate (aquarium) , tandem , combinatorial chemistry , computer science , stereochemistry , medicinal chemistry , organic chemistry , materials science , biology , ecology , composite material
An unexpected palladium(0)‐catalyzed cyclization of 1 with 2 leads to derivatives 3 or 4 . This reaction allows for broad substrate diversity and proceeds through a proposed sequential process involving regioselective intramolecular carbopalladation.