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Probing Biomolecules by Laser‐Induced Acoustic Desorption: Electrons at Near Zero Electron Volts Trigger Sugar–Phosphate Cleavage
Author(s) -
Bald Ilko,
Dąbkowska Iwona,
Illenberger Eugen
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803382
Subject(s) - electron , biomolecule , sugar phosphates , phosphate , dna , cleavage (geology) , chemistry , desorption , rna , atomic physics , chemical physics , materials science , physics , biochemistry , organic chemistry , adsorption , quantum mechanics , fracture (geology) , composite material , gene
Making the cut : Electrons at energies close to 0 eV have been shown to be resonantly captured by gas‐phase D ‐ribose‐5‐phosphate (a model compound for the DNA and RNA backbone) with subsequent cleavage of the sugar–phosphate linkage (see scheme). This supports the idea that breakage of DNA strands by electrons at very low energies are triggered by dissociative electron attachment directly to the DNA/RNA backbone.