Premium
Asymmetric Intramolecular Oxa‐Michael Addition of Activated α,β‐Unsaturated Ketones Catalyzed by a Chiral N , N ′‐Dioxide Nickel(II) Complex: Highly Enantioselective Synthesis of Flavanones
Author(s) -
Wang Lijia,
Liu Xiaohua,
Dong Zhenhua,
Fu Xuan,
Feng Xiaoming
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803326
Subject(s) - enantioselective synthesis , intramolecular force , scope (computer science) , substrate (aquarium) , catalysis , chemistry , nickel , combinatorial chemistry , organic chemistry , computer science , programming language , oceanography , geology
The title reaction provides a promising approach for the synthesis of chiral flavanones with broad substrate scope and is tolerant to air and moisture. Good to excellent enantioselectivities and high yields were achieved for most substrates under mild conditions.