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A General and Selective Copper‐Catalyzed Cross‐Coupling of Tertiary Grignard Reagents with Azacyclic Electrophiles
Author(s) -
Hintermann Lukas,
Xiao Li,
Labonne Aurélie
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803312
Subject(s) - electrophile , reagent , catalysis , supramolecular chemistry , combinatorial chemistry , chemistry , ligand (biochemistry) , coupling (piping) , copper , grignard reagent , organic chemistry , molecule , materials science , biochemistry , receptor , metallurgy
Bulky heterocycles : A highly selective catalytic cross‐coupling reaction of tertiary Grignard reagents with chloroazacycles provides a shortcut to heterocyclic building blocks for applications in pharmaceutical chemistry and supramolecular chemistry, or as ligand precursors in transition‐metal catalysis (see scheme).