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Crystal Structure of a Molecular Assembly Line
Author(s) -
Weissman Kira J.,
Müller Rolf
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803293
Subject(s) - assembly line , crystal (programming language) , domain (mathematical analysis) , molecular machine , ribosomal rna , molecule , crystal structure , bacteria , chemistry , nanotechnology , computational biology , crystallography , materials science , biology , computer science , biochemistry , genetics , programming language , gene , engineering , mathematics , organic chemistry , mechanical engineering , mathematical analysis
Domain event : Non‐ribosomal peptide synthetases (NRPSs) are gigantic molecular machines which assemble natural products of high structural complexity in bacteria and fungi. A team of researchers has recently solved the first crystal structure of an entire module of domains from an NRPS system, a breakthrough achievement for the field.