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A Near‐Infrared Squaraine Dye as a Latent Ratiometric Fluorophore for the Detection of Aminothiol Content in Blood Plasma
Author(s) -
Sreejith Sivaramapanicker,
Divya Kizhumuri P.,
Ajayaghosh Ayyappanpillai
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803194
Subject(s) - fluorophore , chemistry , fluorescence , photochemistry , infrared , plasma , optics , physics , quantum mechanics
Hunt for thiols : A nucleophilic thiol attack on a weakly fluorescent near‐infrared (NIR) squaraine dye results in a conjugation break to form an adduct that absorbs in the UV/Vis region and is highly fluorescent. This fluorophore allows the selective detection of thiols either by colorimetry or fluorescence (see picture). The probe is suitable for the detection and estimation of the total aminothiol content in human blood plasma.