Premium
A General Palladium‐Catalyzed Suzuki–Miyaura Coupling of Aryl Mesylates
Author(s) -
So Chau Ming,
Lau Chak Po,
Kwong Fuk Yee
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803193
Subject(s) - palladium , aryl , nucleophile , catalysis , chemistry , alkyl , medicinal chemistry , coupling (piping) , combinatorial chemistry , organic chemistry , materials science , metallurgy
Catalyze this! The first palladium‐catalyzed Suzuki–Miyaura coupling of unactivated aryl mesylates is reported, with not only arylboronic acids, but also other organoboron nucleophiles (see picture; Z=B(OH) 2 , BF 3 K, BPin). The reaction conditions are compatible with various common functional groups (R 1 =alkyl, OMe, CHO, CO, CN, CO 2 R′, heteroaryl).