Copper‐Catalyzed Highly Enantioselective Carbenoid Insertion into SiH Bonds | Zendy

Zhang YongZhen | Zendy; Zhu ShouFei | Zendy; Wang LiXin | Zendy; Zhou QiLin | Zendy

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Copper‐Catalyzed Highly Enantioselective Carbenoid Insertion into SiH Bonds

Author(s) -

Zhang YongZhen,

Zhu ShouFei,

Wang LiXin,

Zhou QiLin

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200803192

Subject(s) - carbenoid , enantioselective synthesis , trifluoromethanesulfonate , catalysis , chemistry , copper , insertion reaction , diimine , combinatorial chemistry , medicinal chemistry , enantiomer , stereochemistry , organic chemistry , rhodium

Complete control : A highly efficient, copper‐catalyzed, asymmetric carbenoid insertion into SiH bonds, using chiral spiro diimine (SIDIM) ligands (see scheme, Ar=2,6‐Cl 2 C 6 H 3 , OTf=trifluoromethanesulfonate), produces a wide range of α‐silylesters, in high yields with excellent enantiomeric excesses. This catalytic system offers unprecedented levels of enantiocontrol for the SiH bond insertion reaction.

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