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Copper‐Catalyzed Highly Enantioselective Carbenoid Insertion into SiH Bonds
Author(s) -
Zhang YongZhen,
Zhu ShouFei,
Wang LiXin,
Zhou QiLin
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803192
Subject(s) - carbenoid , enantioselective synthesis , trifluoromethanesulfonate , catalysis , chemistry , copper , insertion reaction , diimine , combinatorial chemistry , medicinal chemistry , enantiomer , stereochemistry , organic chemistry , rhodium
Complete control : A highly efficient, copper‐catalyzed, asymmetric carbenoid insertion into SiH bonds, using chiral spiro diimine (SIDIM) ligands (see scheme, Ar=2,6‐Cl 2 C 6 H 3 , OTf=trifluoromethanesulfonate), produces a wide range of α‐silylesters, in high yields with excellent enantiomeric excesses. This catalytic system offers unprecedented levels of enantiocontrol for the SiH bond insertion reaction.