Highly Selective Metal Catalysts for Intermolecular Carbenoid Insertion into Primary CH Bonds and Enantioselective CC Bond Formation | Zendy

Thu HungYat | Zendy; Tong Glenna SoMing | Zendy; Huang JieSheng | Zendy; Chan Sharon LaiFung | Zendy; Deng QingHai | Zendy; Che ChiMing | Zendy

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Highly Selective Metal Catalysts for Intermolecular Carbenoid Insertion into Primary CH Bonds and Enantioselective CC Bond Formation

Author(s) -

Thu HungYat,

Tong Glenna SoMing,

Huang JieSheng,

Chan Sharon LaiFung,

Deng QingHai,

Che ChiMing

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200803157

Subject(s) - carbenoid , enantioselective synthesis , porphyrin , chemistry , catalysis , intermolecular force , primary (astronomy) , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , molecule , rhodium , physics , astronomy

Primary CH bond activation! A Rh complex of bis‐pocket porphyrin I catalyzes carbenoid insertion into the CH bonds of n ‐alkanes with a primary/secondary selectivity (per CH bond) of up to 11.4:1 (see picture). Enantioselective secondary CH bond functionalization catalyzed by a Rh complex of Halterman's chiral porphyrin features up to 93 % ee. These reactions exhibit up to 6477 turnovers after the catalyst was recycled five times.

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