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Bioreversible Protection of Nucleoside Diphosphates
Author(s) -
Jessen Henning Jacob,
Schulz Tilmann,
Balzarini Jan,
Meier Chris
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803100
Subject(s) - prodrug , nucleoside , chemistry , membrane , nucleoside analogue , enzyme , cell , biochemistry , biophysics , biology
Going incognito : A new prodrug approach has been developed to facilitate the diffusion of highly polar polyphosphorylated nucleosides across cell membranes (see scheme). Inside the cell, the masking groups on the nucleoside diphosphate should be cleaved rapidly by enzymes to release the antiviral active cargo.