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Coiled‐Coil Lipopeptides Mimicking the Prehairpin Intermediate of Glycoprotein gp41
Author(s) -
Schuy Steffen,
Schäfer Edith,
Yoder Nicholas C.,
Hobe Stephan,
Kumar Krishna,
Vogel Reiner,
Janshoff Andreas
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803080
Subject(s) - function (biology) , glycoprotein , computational biology , computer science , virus , virology , chemistry , biology , biochemistry , microbiology and biotechnology
A sheep in wolf's clothes? Mimicking the crucial conformational step in viral fusion promises to be an efficient method to detect potential antagonists of retroviral infection (see scheme). Reconstituted lipopeptides derived from the N peptides of the class I virus fusion protein of SIV serve as receptors for potential inhibitors that function like the C peptides of the virus protein.