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Total Synthesis of Callystatin A by Titanium‐Mediated Reductive Alkyne–Alkyne Cross‐Coupling
Author(s) -
Reichard Holly A.,
Rieger Jude C.,
Micalizio Glenn C.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200803031
Subject(s) - alkyne , modular design , transformation (genetics) , coupling (piping) , chemistry , computer science , combinatorial chemistry , operating system , materials science , catalysis , organic chemistry , biochemistry , metallurgy , gene
Using a modular approach : A concise synthesis of callystatin A has been developed. The modular pathway provides access to the highly unsaturated skeleton of the leptomycin natural products by using a complex titanium‐mediated reductive alkyne–alkyne cross‐coupling reaction as the key transformation (see scheme; TBS= tert ‐butyldimethylsilyl).
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