Premium
Solid‐Supported Synthesis and Biological Evaluation of the Lantibiotic Peptide Bis(desmethyl) Lacticin 3147 A2
Author(s) -
Pattabiraman Vijaya R.,
McKinnie Shaun M. K.,
Vederas John C.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802919
Subject(s) - lantibiotics , lanthionine , thioether , peptide , chemistry , combinatorial chemistry , stereochemistry , bacteriocin , bacteria , biochemistry , biology , organic chemistry , antimicrobial , genetics
Lan‐tastic! A lanthionine analogue of lacticin 3147 A2 (Lan‐A2, 2 ) containing multiple thioether bridges (see picture) has been successfully synthesized by a combination of solid‐ and solution‐phase peptide synthesis. Chemically synthesized Lan‐A2 ( 2 ) exhibits synergistic biological activity similar to natural lacticin A2 ( 1 ) in the presence of natural lacticin A1 against Gram‐positive bacteria.