Solid‐Supported Synthesis and Biological Evaluation of the Lantibiotic Peptide Bis(desmethyl) Lacticin 3147 A2 | Zendy

Pattabiraman Vijaya R. | Zendy; McKinnie Shaun M. K. | Zendy; Vederas John C. | Zendy

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Solid‐Supported Synthesis and Biological Evaluation of the Lantibiotic Peptide Bis(desmethyl) Lacticin 3147 A2

Author(s) -

Pattabiraman Vijaya R.,

McKinnie Shaun M. K.,

Vederas John C.

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200802919

Subject(s) - lantibiotics , lanthionine , thioether , peptide , chemistry , combinatorial chemistry , stereochemistry , bacteriocin , bacteria , biochemistry , biology , organic chemistry , antimicrobial , genetics

Lan‐tastic! A lanthionine analogue of lacticin 3147 A2 (Lan‐A2, 2 ) containing multiple thioether bridges (see picture) has been successfully synthesized by a combination of solid‐ and solution‐phase peptide synthesis. Chemically synthesized Lan‐A2 ( 2 ) exhibits synergistic biological activity similar to natural lacticin A2 ( 1 ) in the presence of natural lacticin A1 against Gram‐positive bacteria.

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