Premium
The Absolute Configuration of Rhizopodin and Its Inhibition of Actin Polymerization by Dimerization
Author(s) -
Hagelueken Gregor,
Albrecht Simone C.,
Steinmetz Heinrich,
Jansen Rolf,
Heinz Dirk W.,
Kalesse Markus,
Schubert WolfDieter
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802915
Subject(s) - absolute configuration , chemistry , actin , ternary complex , polymerization , stereochemistry , ternary operation , polymer , biochemistry , organic chemistry , enzyme , computer science , programming language
Three's company : Rhizopodin is a cytostatic macrolide and a potent actin depolymerizer produced by the myxobacterium Myxococcus stipitatus. A crystal structure analysis of the rhizopodin/actin complex reveals that rhizopodin is a C 2 ‐symmetric bislactone (see formula). The ternary complex supports the mode of rhizopodin‐induced actin dimerization and reveals the absolute configuration and biologically active conformation of this macrolide.