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Switchable Motion of DNA on Solid Supports
Author(s) -
Elbaz Johann,
TelVered Ran,
Freeman Ronit,
Yildiz Huseyin Bekir,
Willner Itamar
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802905
Subject(s) - nucleic acid , methylene blue , dna , chemistry , adenosine monophosphate , inosine , adenosine deaminase , electrochemistry , redox , solid surface , biophysics , adenosine , biochemistry , combinatorial chemistry , biology , inorganic chemistry , electrode , photocatalysis , catalysis , chemical physics
Tracking the changes : The switchable translocation of a nucleic acid strand with a methylene blue (MB + ) redox group on a DNA track associated with a surface can be triggered by adenosine monophosphate (AMP, green) and adenosine deaminase (purple, see picture); the latter converts AMP into inosine monophosphate (orange). The motion of the nucleic acid can be followed by the electrochemical, photo‐electrochemical, and fluorescence signals.