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Asymmetric Aza‐Michael Reactions of α,β‐Unsaturated Ketones with Bifunctional Organic Catalysts
Author(s) -
Lu Xiaojie,
Deng Li
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802785
Subject(s) - bifunctional , chemistry , enantioselective synthesis , library science , computer science , catalysis , organic chemistry
Synergy makes it possible : Bifunctional cinchona alkaloids are found to promote the first highly enantioselective organocatalytic aza‐Michael reactions with α,β‐unsaturated ketones. In addition to utilizing practical catalysts, readily accessible substrates, and commercially available reagents, this reaction affords a synthetically valuable scope that is complimentary to existing methods catalyzed by chiral metal complexes.