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Nickel‐Catalyzed Negishi Cross‐Couplings of Secondary Nucleophiles with Secondary Propargylic Electrophiles at Room Temperature
Author(s) -
Smith Sean W.,
Fu Gregory C.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802784
Subject(s) - negishi coupling , electrophile , nucleophile , nickel , catalysis , chemistry , ligand (biochemistry) , combinatorial chemistry , organic chemistry , biochemistry , receptor
Mild thing : The first nickel‐based catalysts for cross‐couplings of secondary organometallic nucleophiles with secondary alkyl electrophiles have been developed. Thus, Negishi reactions proceed under mild conditions (at room temperature with no basic activators) in the presence of NiCl 2 ⋅glyme and a tridentate ligand (see scheme).