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Photocontrolled Cell Adhesion on a Surface Functionalized with a Caged Arginine‐Glycine‐Aspartate Peptide
Author(s) -
OhmuroMatsuyama Yuki,
Tatsu Yoshiro
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802731
Subject(s) - peptide , hela , adhesion , glycine , chemistry , cell adhesion , arginine , cell , biochemistry , biophysics , stereochemistry , amino acid , biology , organic chemistry
Sticking to the time and the place : Cell adhesion can be photocontrolled spatiotemporally on a photoresponsive culture dish functionalized with a caged cell‐adhesion motif, namely a nitrobenzyl‐substituted argine‐glycine‐aspartate peptide. Photolysis of the dish cleaves the nitrobenzyl group to produce the active peptide to which HeLa cells can adhere (see micrograph: left half, irradiated).