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Gold(I)‐Catalyzed Tandem Reactions Initiated by 1,2‐Indole Migrations
Author(s) -
Sanz Roberto,
Miguel Delia,
Rodríguez Félix
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200802660
Subject(s) - indole test , indene , tandem , carbene , catalysis , chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , materials science , composite material
Take your pick! Indene‐containing indole scaffolds have been catalytically prepared from C3‐propargylated indoles by tandem reactions involving an initial 1,2‐indole migration. This unprecedented process generates a gold carbene complex and proceeds through either a formal CH insertion or a Nazarov cyclization (see scheme).